Nexium and High Calcium Blood Tests

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BobbyT10
Regular Member


Date Joined Feb 2006
Total Posts : 31
   Posted 5/24/2007 9:40 PM (GMT -6)   
My Doctor's office called me recently to tell me that my last blood test showed high calcium (norm is 10.4, I have 10.6).  I have been doing alot of internet research to find causes of high calcium: parathyroid tumor, sarcoidosis, bone cancer, padgets bone disease, chronic kidney disease..... but when I searched webmd.com for high calcium I found an article that linked nexium http://www.webmd.com/heartburn-gerd/news/20061227/acid-reflux-durgs-may-up-fractures to hip fractures, stating that:
 
It's not entirely clear why this happens. Stomach acid helps the body absorb calcium, which is needed for healthy bones. But it only takes a little bit of acid to do this. That may be why Yang's team finds only a "modest" fracture risk with low doses of proton-pump inhibitors and a "much higher magnitude" risk with high doses.

It may also explain why they found no link between other types of GERD drugs and hip fracture. Other GERD treatments include histamine blockers -- referred to as H2 antagonists; they specifically block the histamine type 2 receptor, preventing histamine from stimulating acid-producing cells. H2 antagonists include Tagamet, Zantac, Axid, and Pepcid

Has anybody heard anything about this, any idea what qualifies as "high dosage".  It makes me kind of worried to continue nexium, but I am lost without it.  I do have doctors appointments so I am "talking to my doctor" in case anyone wants to suggest that :).  I'd just like to see what other people have to say or if anyone has had simliar blood tests.

bdr1
Regular Member


Date Joined Aug 2005
Total Posts : 121
   Posted 5/25/2007 2:23 PM (GMT -6)   
While this was an early concern with the introduction of PPI's. There was a large-scale study examining the effects of vitamin absorption with Prilosec (the parent drug of Nexium) - which demonstrated that Calcium absorption was not affected with almost 18 years of daily drug exposure.

Hope this helps!
ckgMD

BobbyT10
Regular Member


Date Joined Feb 2006
Total Posts : 31
   Posted 5/26/2007 7:05 AM (GMT -6)   
But in my article there was a study that was done recently on nexium, not Prilosec. How can we disregard that?  Also calcium is a mineral not a vitamin.  Was the study for vitamins and minerals?

Post Edited (BobbyT10) : 5/26/2007 7:26:18 AM (GMT-6)


bdr1
Regular Member


Date Joined Aug 2005
Total Posts : 121
   Posted 5/26/2007 11:02 AM (GMT -6)   
If you find the article -- would you mine posting it? I've never seen this as a problem in patients treated with PPI's. The most recent trials that I read with Nexium were confounded by the fact that they utilized a population which had decreased calcium absorption already (the elderly).

BobbyT10
Regular Member


Date Joined Feb 2006
Total Posts : 31
   Posted 5/28/2007 6:48 AM (GMT -6)   
http://www.webmd.com/heartburn-gerd/news/20061227/acid-reflux-durgs-may-up-fractures?page=1

bdr1
Regular Member


Date Joined Aug 2005
Total Posts : 121
   Posted 5/31/2007 3:12 PM (GMT -6)   
hey bobby --- yes, this is the study which only examined older people. unfortunately - this is a population with decreased calcium absorption already.
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