erosions despite PPIs

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Veteran Member

Date Joined Sep 2005
Total Posts : 1744
   Posted 7/16/2007 7:13 AM (GMT -6)   
Hi all,
I had an upper endoscopy done about 5 weeks ago.  I have erosive gastritis and erosive esophagitis despite taking a double-dose PPI every day and 300 mg/ zantac every night--for 5 years!  Biopsies came back negative for h. pylori (I've had h. pylori before), which is certainly a blessing.  GI thinks the erosions may be caused either by bile reflux or complicated acid reflux.  I'm scheduled for a HIDA scan this week to see if my gall bladder is functioning.  If that's normal, GI doctor is going to switch my PPI.  I currently take aciphex; he mentioned switching me to zegeret because it has something extra in it that other PPIs don't have?  I had always understood that all PPIs are created equal; no one drug is really better than another.  It seems to me, though, that it is a very individual thing.  Some PPIs work for some; others do not. 
What do you do when PPI therapy is not effective?  The aciphex helps with my symptoms--I could not function without it.  But I still have erosions (next step is ulcers) despite taking the aciphex, and other PPIs prove to be about the same, what are my options?  Anyone have experience with this?
Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan

Veteran Member

Date Joined Dec 2006
Total Posts : 722
   Posted 7/16/2007 4:51 PM (GMT -6)   

elcamino, i'm sorry to hear that you are going through this.  i know that, for me, the ppis work for the esophagus but not for the throat.  My throat problems are very cumbersome and never getting better.

I read somewhere that some people have to take it 3 times a day!  I might try that for me (since I am refluxing for 24 hours a day!!)

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