Is that the same as Zantac 75 or Zantac 150? I am not sure what Omeprazole is unless it is a PPI. But I definitely know my Zantac I was taking says not to take it with another drug used for that purpose like the PPI's. So I stopped taking the nightly Zantac. Actually that is the same from what I read as Prilosec which is now over the counter. You might want to check and see if there are any drug interactions between it and the Zantac type product before starting it. Good luck.