I just started taking zegerid a couple of weeks ago. I had been taking aciphex for the last 5 years. From what I can tell so far, it doesn't seem all that different from the aciphex? The only thing I've noticed is that you do have to take it at least 30 minutes prior to eating or it doesn't work. Kind of a pain because I keep on forgetting my afternoon dose and then have acid reflux all night. For all I know, though, perhaps you are supposed to take all of the PPIs prior to eating. My previous GI never gave me any directions for how to take them.
In answer to your question, though, zegerid works. I don't know if it works any better than the other PPIs, though.
Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan