They have not done a biopsy on my wheals (lumps) but a ton of blood tests.(all normal) The last testing went to the Mayo clinic. That is suppose to determine if this is an autoimmune disease in my case. If so then it is a problem with my own immune system and there is an unlikely external cause (food,mites,etc) In any case if you can't find an external trigger that is causing this then you can only treat the symptoms until/if it decides to leave. I am curently taking 2-180mg Allegra,2-Tagamet,1-Singulair,1-10mg Atarax,1-10mg Claritin (sp). Each of these drugs I am taking daily. I will most likely up the dosage as this is not helping too much.
I strongly advise you to take a look at the International Chronic Urticaria Society (ICUS) website. You will find out everything you want to know about this stuff (all the treatmets,blood tests,drugs,etc.) There is a very active daily forum there also. Believe me your are not the only one suffering from this. I am one of the few males who has this as it is primarily a womens disease.
After visiting the ICUS website , I presented my doctor with a 1/2 inch stack of papers listing studies,drugs,test cases,etc about Urticaria that I pulled from that website. I wanted to make sure he was giving me the proper treatment. He was.
Hope this helps