I've had CU for almost a year now and it has been a nightmare! I have previous posts on here so I won't go into to much detail on my struggle with CU. In October 2009 I decided to face my depression and anxiety and I started taking cipralex (antidepressant), and ativan (antianxiety). It has taken a few months but starting in mid-January I began noticing that my hives were getting better! They're still not gone completely but they are a lot better than they were. They still tend to get worse at my time of the month. I know having CU sunk me into a bad depression but I think I've had anxiety for many years. I don't know if this is the cause of my hives but I thought I'd post this incase it helps somebody else. I'll keep posting on my progress. Hang in there CU sufferers!