I'm a lifelong asthmatic and started Xolair about two years ago. There's a posting here somewhere about my experience with it, the short version is that I'm considered a severe, persistent asthmatic and was on Pulmicort twice a day with albuterol in the mix at least two times a day. After being treated with Xolair, I'm off the Pulmicort unless I get a cold or, as now, when the spring pollen count is off the charts. I also climb a 900 foot waterfall and/or trailrun about 3 miles each day with the dog.
I was one of those asthmatics years ago who had multiple courses of antibiotics and prednisone often related to getting a cold, but just as often not related to anything I could put my finger on.
I highly recommend anyone whose symptoms are not in control to check back in with their doctor. Remember, if you are newly on one of the steroidal inhalers, it may take up to 10 days to see any real relief. Your doctor may want to put you on prednisone for a short taper to help you through the adjustment period.
I also recommend educating yourself about how to boost your immune system. Asthma is considered an immune system type disease because, generally, your histamine (allergic inflammation) response is out of control. And all the meds you take can leach nutrients out of your system and affect your adrenal glands (which may result in the fatigue you're feeling).
Also, look into taking a yoga class or finding a workshop on "pranayama" (pronounced PRAH nah yahm), which is yogic breathing. When I started on my long journey from unable to walk too far to where I am now, yogic breathing techniques and yoga itself, helped unlock the tightness in my ribcage thus allowing my lungs to expand more easily. These techniques also teach you how to take a complete breath, most of us breathe very shallowly. And, the most important part is emptying your lungs completely. It's not so much that you can't get air in with asthma, you can't get it completely out so you're carbon dioxide level builds up, creating that panicked, "I'm drowning," feeling. And I also recommend, once your symptoms are under control, start exercising SLOWLY!!!!! A little at a time. I started out doing about a tenth of a mile, roughly five hundred feet. That's the distance along a line of five telephone poles. Take it slow, increase as you can and you will recover old strength. I did, I was a high school track star...a sprinter who, by the age of 23, couldn't go upstairs without my albuterol either.
And keep at your doctor. If he or she is dismissive, ask to see a pulmonary specialist and an allergist if you haven't already. Asthma is not a cookie cutter disease and one inhaler may not be the best for all patients (although the insurance company doesn't realize that!!). If your request to be referred to specialists is denied...find another doctor.
Good luck to all, and by the way, I'm 47 now and intend climbing that little mountain every day for as long as my knees hold out!!