Posted 8/7/2005 11:06 PM (GMT -6)
I did some lit search:
In 1880, Hardaway first described a kind of chronic, hard and globular skin nodules which were characterised clinically by an intense itch . The disease was named prurigo nodularis by Hyde in 1909 . Lately, many studies were performed to detect its causes and mechanisms. Some factors, such as emotional stress, seem to be contributory in certain cases. Around 80% of the patients have an atopic constitution and it has been claimed that in 20% the condition starts after an insect bite . Histologically, the disease is characterized by irregular acanthosis, hyperkeratosis and an inflammatory cell infiltration. The neurohistological changes includes a massive neural hyperplasia , which has been further verified by neuronal peptide staining as well as protein gene product 9.5 (PGP 9.5) and nerve growth factor receptor (NGFr) staining [5, 6, 7]. Recently, mast cells, neutrophils and eosinophils were investigated in order to enlighten the mechanism of the disease . But, the etiology is still not clear.
Treatment of prurigo nodularisnext term with topical capsaicin
Sonja Ständer MDb, Thomas Luger MDa and Dieter Metze MDb
From the Department of Dermatology,a and the Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin,b University of Muenster.
Available online 15 May 2002.
Background: Prurigo nodularis is an eruption of lichenified or excoriated nodules caused by intractable pruritus that is difficult to treat. Therefore the antipruritic efficacy of capsaicin seemed to be of particular interest because this alkaloid, extractable from red pepper, interferes with the perception of pruritus and pain by depletion of neuropeptides in small sensory cutaneous nerves. Objective: The aim of this concentration- and regimen-ranging study was to evaluate the efficacy, safety, and practicability of capsaicin in the topical treatment of prurigo nodularis in a large series of patients. Methods: A total of 33 patients with prurigo nodularis of various origins were selected to receive capsaicin (0.025% to 0.3%) 4 to 6 times daily for 2 weeks up to 10 months. The consecutive follow-up period was up to 6 months. In 7 patients, skin biopsy specimens were taken before, during, and after therapy and investigated histologically, immunohistochemically, and ultrastructurally. Results: All 33 patients could be evaluated for efficacy. After cessation of the symptoms of neurogenic inflammation, such as burning sensations or erythema, all of them experienced a complete elimination of pruritus within 12 days. In addition, capsaicin largely contributed to the gradual healing of the skin lesions. After discontinuation of the therapy, pruritus returned in 16 of 33 patients within 2 months. At the ultrastructural level, no degenerative changes of cutaneous nerves could be found during or after capsaicin therapy. Depletion of substance P was demonstrated by confocal laser scanning microscopy thus confirming the specific effect of capsaicin in vivo. Conclusion: Topical treatment of prurigo nodularis with capsaicin proved to be an effective and safe regimen resulting in clearing of the skin lesions. (J Am Acad Dermatol 2001;44:471-8.)
The connection of this disease with Alzheimers may be due to the meds taken to treat Alzheimers.
cholinesterase inhibitors (Razadyne, Exelon, Aricept, Cognex): prevent breakdown of acetylcholine
Namenda: N-methyl D-aspartate (NMDA) antagonist, regulating glutamate
Both groups increase neurotransmitters to counter neurodegredation and might be responsible for the neural hyperplasia as stated in the above article, resulting in prurigo nodularis.
Not a doctor, but I hope this helps some.
Asacol- 3x3 daily
Prednisone (tapering, 20mg right now)
GNC womens formulated iron (I know I'm a guy but these are way better than ferrous sulfate tabs)- 1 daily
Mens 1 a day vit- 1 daily
Ultra Concentrated Omega's- 2x daily
Concentrated Aloe vera extract and Whey protein in my breakfast or post-workout SCD fruit smoothie
Going into Remission (I hope):
Working out 4-6 day weekly