You might want to check the web site called Drugs.com. It will tell you all about the medications she is taking and side effects, too. Here is a link about Lunesta from Drugs.com. I picked that since you said her confusion gets worse after her nighttime regimen. This also says that antidepressants and narcotics can interact with Lunesta. It could be this combination of drugs. You might also want to check with your doctor or pharmacist. The pharmacist might know and it won't cost you a cent for the info.