Leukine as possible treatment

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lgonis
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Date Joined Jan 2015
Total Posts : 1
   Posted 1/20/2015 10:53 PM (GMT -7)   
I've read that leukine is being testing in a clinical trial to study possible effects on Alzheimers. It was noticed by researchers that rheumatoid arthritis patients almost never developed Alzheimers. One hypothesis that has been successfully tested in mice is that the protein GMCSF is released into the blood in RA patients. This protein then gets into the brain and prevents alzheimers. This same protein is in the drug leukine.

Leukine is an FDA approved drug used after bone marrow transplants or after chemotherapy to treat neutropenia, a side effect of the chemo. My understanding is that in the US any medical doctor can prescribe a drug for indications other than the approved indication, "off-label.' However in some cases this off label use may not be reimbursed by insurance.

Does anyone have experience or knowledge of any doctors prescribing leukine off label for alzheimers? I'm sure someone has picked up on this possibility.

We just returned from another disappointing visit to the neurologist with my mother in law, who has alzheimers. The doc basically offered no good treatments other than what she has been taking - Numenda and Exelon - which he admitted don't really do anything. Leukine is in the early stages of testing and if successful wouldn't be approved until too late for us. We are looking for options if anyone can help

thanks
Lou
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