New Eye Test Can Detect Alzheimer’s Disease Many Years Prior to Symptoms Emerging

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Date Joined Jul 2006
Total Posts : 148
   Posted 8/19/2017 12:26 PM (GMT -6)   
This looks very promising for proactive treatment of Alzheimer’s in the future. Not sure how much is okay to paste in so I will leave link too.


. In a study of 16 patients at Cedars-Sinai Hospital in Los Angeles with Alzheimer’s found they had more than twice as much beta-amyloid in their retinas.  Neurosurgeon Professor Maya Koronyo-Hamaoui, of Cedars-Sinai Medical Center, Los Angeles, said: “Analysis of retinal amyloid index (RAI) scores showed a 2.1-fold increase in Alzheimer’s disease patients.”

In early human development in the womb, the retina of the eye is formed from the same tissue as the brain.  Even before this study there has been a suspicion that there is a link between the ratio of beta-amyloid protein in the eye and amyloid in the brain.  There is even a disease reference to 'dementia of the eye' and age-related macular degeneration (AMD) is linked to a buildup of beta-amyloid proteins in the retina.  The Cedars-Sinai team in an article entitled “Retinal Amyloid Pathology and Proof-of-Concept Imaging Trial in Alzheimer’s Disease” published recently in JCI Insight, say they believe beta-amyloid begins to accumulate in the eyes maybe 20 years or more before symptoms develop in the brain.

The non-invasive technique developed by the Cedars-Sinai team with investigators at NeuroVision Imaging, Commonwealth Scientific and Industrial Research Organisation, University of Southern California, and UCLA
have their patients drink a solution containing the natural fluorescent yellow extract curcumin, the main chemical in the curry spice turmeric. Besides curcumin's natural fluorescent glow, in a micronized form it can cross the blood-brain and blood-retina barrier then binds to the sticky amyloid plaques.  The curcumin solution highlights the amyloid deposits at the back of the eye using a portable extremity imaging device. We recently reviewed on the best forms of curcumin supplements here.

Co-senior study investigator Keith Black, M.D., chair of Cedars-Sinai's department of neurosurgery and director of the Maxine Dunitz Neurosurgical Institute stated: "Our hope is that eventually the investigational eye scan will be used as a screening device to detect the disease early enough to intervene and change the course of the disorder with medications and lifestyle changes."
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