How long does it take for Zoloft to work?

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Regular Member

Date Joined Jan 2008
Total Posts : 88
   Posted 5/7/2008 1:51 PM (GMT -6)   
I've heard anywhere from 2 - 8 weeks. If you're on it, tell me how long it took you to really feel the effects.

Crohn's Diagnosed in 1996.
Currently on Humira - One syringe every other week.
Now in remission.
Have tried Prednisone, Pentasa, Flagyl, Cipro, and Imuran in the Past - they aren't effective now.
Hospitalized only once, but that was enough!

Elite Member

Date Joined Apr 2007
Total Posts : 32602
   Posted 5/7/2008 3:31 PM (GMT -6)   

Hi there, this is Kitt.  I have been told by my Doctor that 4-6 weeks is the average for the medication to kick in completely and this is for most of the ADs.  It also will depend on how your body handles the medication.

You won't notice a sudden cure from any of the meds as there is no miracle pill but working together with you physician/therapist the medication should help you. this is my 2 cents worth. :)

I do not take this med but do use the Cymbalta.

Take care and keep posting.


Kitt, Moderator: Anxiety ~ Panic 
Not a mental health professional of any kind
It is health that is real wealth and not pieces of gold and silver.~Mahatma Gandhi~

Regular Member

Date Joined Nov 2007
Total Posts : 146
   Posted 5/7/2008 5:45 PM (GMT -6)   
I have been on Lexapro since February. Although I did feel better initally I had to up the dose twice. NOW I think I am feeling the full effect. It may take some dose adjusting. :)

Elite Member

Date Joined Jan 2005
Total Posts : 24909
   Posted 5/9/2008 5:47 AM (GMT -6)   
I have also been told 4 to 6 weeks to feel the full effect of this med and others
I wish you all the best

Take care

  DX With Crohns,Pyoderma Gangrenosum,Anxiety/Panic,Fibro & Other DD
Moderator @ Anxiety Panic..Alzheimer's..Co mod @ Crohns
                               FIGHT the FIGHT with all YOU HAVE

Veteran Member

Date Joined Sep 2006
Total Posts : 510
   Posted 5/9/2008 6:51 AM (GMT -6)   
When  I first started on zoloft I noticed some improvement within 2 weeks but the full effects are usually 6 to 8weeks.
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