Anyone's meds (antidepressants) stopped working after many years?

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Regular Member

Date Joined May 2005
Total Posts : 229
   Posted 2/17/2010 12:59 PM (GMT -7)   
If so, what did you do? I feel like mine might be.

Regular Member

Date Joined Nov 2009
Total Posts : 82
   Posted 2/17/2010 2:42 PM (GMT -7)   
I'm on anti-depressants and they work for about two years and then we have to change them to something different. So far I've been lucky and have been able to find others to go on, but I'm always fearful that they might not always be the case. I've been on abilify for awhile now and they are going to have to take me off it and try something different because it isn't working anymore. I hope that you are able to find some meds that help you and that last awhile. It's always trial and error...

Regular Member

Date Joined May 2005
Total Posts : 229
   Posted 2/17/2010 4:27 PM (GMT -7)   
Wow! God that's gotta be very hard to deal with. My psych says that other meds would be the same way (eg, they wouldnt help) and its also not worth it to try new ones due to having to go thru all the side effects again. So i feel like I have NO options. I tried adding Abilify...I slept 4 hrs in 2 days so went off that quick.

Regular Member

Date Joined Feb 2010
Total Posts : 114
   Posted 2/17/2010 5:09 PM (GMT -7)   
I think you should consider seeing a new psychiatrist. The meds are NOT all the same. I have had to change mine many times to get it right after things quit working well. They all work just a little differently. Some of them are very similar, but a good psychiatrist should be able to find an alternative medicine.
Abilify made me feel like a zombie.
Best of luck to you!


Forum Moderator

Date Joined Apr 2007
Total Posts : 32602
   Posted 2/17/2010 5:17 PM (GMT -7)   
Mine pooped out after years and years...............I saw my physician and after trying many of the newer meds I have finally found a med combo that works well for me.

Do talk with your physician and see what he/she feels may be the best thing to do.



Veteran Member

Date Joined Dec 2005
Total Posts : 1768
   Posted 2/17/2010 8:12 PM (GMT -7)   
I was on lexapro for a long time, and had to switch because it just stopped working. It took a while of trying different meds, but I've gotten a combo that works for me now. I found that some kept me from sleeping, others gave me nightmares, etc, but with time and patience you can find meds that work for you.

I understand your frustration. Maybe your dr will just have to have you try some different meds to see what works for you.

32 yr old female-dx with Crohn's in '97 after emergency resection and appendectomy, 2nd resection '05, Bilateral pulmonary emboli 10/09
Currently on Humira, Omeprazole, Effexor, Seroquel, Calcium, Vit D, Coumadin

New Member

Date Joined Feb 2010
Total Posts : 3
   Posted 2/17/2010 11:40 PM (GMT -7)   
YES! I joined this site just to answer this. I've been on various SSRI s for 15 years, and we need to change them every 2 years or so. They just quit working - no one seems to know why. The good news is there is some benefit to switching to other SSRIs. I started with Prozac, switched to Paxcil, then Zoloft, then Cymbalta. BTW, Cymbalta is nasty stuff to withdraw from - much more than the others I used.

I just tried switching back to Zoloft (Cymbalta had quit working, plus was unpleasant to withdraw from. I was going to try going pill-free, which I did once for 14 months, but I started a new job and work stress got me down. My Doc put me back on Zoloft last week, just as I left for a ski trip; and I got the mother of all panic attacks. The Doc doesn't know why - he thinks maybe the altitude (6000 ft over sea level) had an effect and made the Zoloft backfire.

I'm going to look for another Doc who will work to get me pill free again. 15 years is too much, and NOTHING is worth another panic attack like that. It could be fatal. I'm been lurking at this healingwell community here:

These programs look like more work than the pills, but I suspect they're healthier.

Post Edited (stitch626) : 2/17/2010 11:45:14 PM (GMT-7)

Forum Moderator

Date Joined Apr 2007
Total Posts : 32602
   Posted 2/18/2010 4:52 AM (GMT -7)   

Thank you and welcome aboard. Your answer was very well thought out and on the money ! :) Please feel comfortable starting a thread of your own if you choose.

We are here to support all and love new members.


New Member

Date Joined Feb 2010
Total Posts : 3
   Posted 2/18/2010 2:09 PM (GMT -7)   
Thanks for the kind words. I've been dealing with anxiety since the 1970s, and groups like this, as well as the newer meds, are making it easier every decade. I found "healingwell" googling for "Linden Method or Panic Away", but when I saw this thread I felt I had to chime in since I've been around the SSRI block a few times.

I'm going to buy one of Linden Method or Panic Away and get to work. I'll report back soon.

And thanks for all you do. These sites are invaluable.


Jan Marie
Veteran Member

Date Joined Sep 2005
Total Posts : 1663
   Posted 2/19/2010 3:32 PM (GMT -7)   

Hi. I've had better luck with meds.  My first tricyclic antidepressants worked for 7 years and then stopped working.  I am now on Effexor and have been for 4 years - so far so good. 

It is worth kissing a few frogs before you find your Prince (or Princess).  A good psychiatric doctor will persevere with you, but it can take a while to come off and to get used to new drugs.


New Member

Date Joined Jul 2015
Total Posts : 1
   Posted 7/4/2015 12:38 AM (GMT -7)   
my diagnosis is major depression and depression runs in my family.

I've used Celexa which was good for a while. Then I needed something better and was switched to flouxetine -Sarafem.
But after 3 years of Sarafem, that also begun to lose the ability to uplift my spirits.
In fact I was on antidepressant but to go without them was worse so I had to continue
with antidepressants.

I talked to my aunt whose depression has gone over 10 years.
She mentioned that she stopped taking anti-depressants completely and
explained that she takes a combination herb supplements and her depression has been
very much improved.
Actually she told me about her improvement but I was not listening cause I didn't believe herbs or supplements can improve something as serious as depression.

But this time I was more attentive to what she was saying because I needed a big change.

So here it is.
The old story was serotonin would need to go to the brain but the changes takes
many weeks to uplift us from our low mood.
But now it is BDNF.
There is a connection between BDNF – a needed brain factor and depression.

Our immune system fights infection or bacteria by causing inflammation but inflammation also leads to low levels of BDNF. But in certain people like us who have family histories of depression, that inflammation can affect our brains more than people without depression.

The herb supplements works against too much release of inflammatory blood factors
and (low ) BDNF goes back to normal and better mood.

But this info is better explained at the source website

The info on BDNF and Depression is from medical research.
It is a good idea to understand what leads to depression and related topics.
The website explains how anti-depressants work and they work against
inflammmation too.

I am very much better on this new remedy.
If your antidepressant isn't working, you should try this.
I highly recommend this.

Forum Moderator

Date Joined Oct 2008
Total Posts : 7043
   Posted 7/4/2015 3:53 AM (GMT -7)   
Hi Kimberry

Welcome to the forum.

Thanks for the information I am always interested in hearing about new ways of treating anxiety/depression and I am pleased to hear that this new remedy is working well for you.

This is an old thread and many of the members that have responded no longer post on the forum so when this happens we lock the thread so it save space on the HW website.

Feel free to start up your own thread that way you will get more replies but could I ask you to have a look at the forum rules which you will find top right just to make sure you are staying within those when giving links to other sites.

Hope you stay with us and keep posting.

I try not to worry about the future -- so I take each day just one anxiety attack at a time.


Diagnosed with:- Asperger's Syndrome, Dyslexia, GAD, Social Anxiety Disorder, Health Anxiety, OCD, Depression and Scheuermann's Disease (Adult)

Medications:- 60mg Prozac, 30mg Mirtazapine , Haloperidol 2mg per day, Dihydrocodeine 180mg per day
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