Centeral Nervous System GABA and nicotine

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Regular Member

Date Joined Jun 2010
Total Posts : 148
   Posted 6/14/2010 8:02 PM (GMT -7)   
Not only suffering from anxiety/panic disorder, I have an addiction to cigarettes, which I'd like to quit before they end up making me sick with something else a lot more dreadful. I just did some research on the relationship between the Central Nervous System chemical GABA and nicotine, and found out that keeping the supply of GABA in the brain high seems to reduce the pleasurable effects of smoking. Thought that was interesting, too, since I'm on three-a-day alprazolam and it seems to be making me crave cigarettes less.

Forum Moderator

Date Joined Apr 2007
Total Posts : 32602
   Posted 6/15/2010 6:15 AM (GMT -7)   
This is quite technical but just posting for FYI to help some understand your post.

Although there are many neurotransmitters in the central nervous system, the peripheral nervous system has only two: acetylcholine and norepinephrine. Why are there so many brain neurotransmitters? Because the functions performed by brain neurotransmitters are not as uniform as they might superficially appear. Some (like glutamate) are excitatory, whereas others (like GABA) are primarily inhibitory.

Nicotinic acetylcholine receptors are present in many tissues in the body and are the best-studied of the ionotropic receptors. The neuronal receptors are found in the central nervous system and the peripheral nervous system.

Have you ever tried any of the "Stop Smoking" programs available. My husband just quit in February after 40 years of smoking.

Good luck,


Elite Member

Date Joined Jan 2005
Total Posts : 24909
   Posted 6/15/2010 7:32 AM (GMT -7)   
i so need to quit
im at the point i dont like taste or smell
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