I can 100% identify with the OP, as well as others here posting about
sudden-onset anxiety and depression from Doxycycline use. I was prescribed it for mild acne, and within about
a week and a half started feeling stranger and stranger. I should have know that something was wrong with this stuff for me, when on the 3rd day of taking it on and empty stomach in the morning, I puked my guts out in the shower - dry heaves for 5+ minutes, even.
Anyway, the first weekend I just felt "off," and it was a mild weekend for me with a light-duty camping trip with the GF. But as the week went on, my memory got shorter and I could not stop surfing websites at work - very OCD-like behaviour
, etc. I also could NOT leave my acne alone, even though it was already starting to improve. And then this weekend, at a competitive event where I am usually an excellent master, I could not remember the course or course subtleties and would get lost over sections that I thought I had just memorized a few minutes earlier. Very strange, very surreal...
And lastly, this morning I took just the Doxy alone again and started to get really anxious and weepy. reflecting on the past week, I had been that way too but I am prone to a little bit of overworrying, so I thing I was just writing the emotions off as that tendency. So, on a whim, I google "doxycycline anxiety" this morning and find account after account of people who have landed in the same circumstance.
So a little more looking around and I find that they because Doxy works to antagonize serotonin 1A receptors, they have used it in mice to create mice that are very prone to "anxious-like" behaviour
s after developing their brains in the presence of a shortage of unblocked HT1A receptors:
Serotonin1A receptor acts during
development to establish normal
in the adultphy.ucsf.edu/~houde/coleman/gross.pdf