Cymbalta / Zoloft or Lexapro

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Regular Member

Date Joined Jun 2017
Total Posts : 59
   Posted 9/19/2017 8:03 AM (GMT -7)   
Hi everybody

Can anyone share their thoughts on the pro's and con's of the Cymbalta, Zoloft and Lexapro? I am going to my GP tomorrow to discuss this because the Buspar I am currently on is not working at all for my anxiety, which is causing depression to set in.

I hear a lot of horror stories, but I'm not sure what other option I have to get my life back in order


Scaredy Cat
Forum Moderator

Date Joined Sep 2006
Total Posts : 27127
   Posted 9/19/2017 8:22 AM (GMT -7)   
Hi Mike,

I am sorry to hear that you are currently struggling. I know how difficult this is.

Have you ever been on an SSRI/SNRI before? It can be hard to say which Rx will be right for you as an individual...b/c everyone has differing needs. What works for one, may not for another...

It's important to remember this when reading reviews...and also to note that people tend to report more negative experiences than neutral or positive ones!

Talking to your doctor will hopefully help you to make an informed decision...

...and you might want to ask your doctor about Genesight type testing to see if this is an option for finding your most compatible med.

Wishing you the best...keep us updated, so we can keep you in support!


"Courage is not the abscence of fear, it is feeling afraid and doing it anyway!"

"Worrying does not empty tomorrow of its empties today of its strength."
Corrie Ten Boom

Panic Syndrome recovery due to CBT

Regular Member

Date Joined Jul 2007
Total Posts : 50
   Posted 9/19/2017 9:56 AM (GMT -7)   
Hi Mike,

Sounds like your are going down the road I was on. My doctor explained that I may have to try several. My doctor started me out I Buspair. Startup and stopping was easy. It worked for me but I could not even get an hours sleep on it. All Doctors must have a checklist. Next was Zoloft, which I had used many years ago with good results but I have had stomach surgery and the GI issues were too tough. I tried Lexapro and made it 6 weeks. Even though at the time it seemed rough, I had some insominia which quickly dissipated and nausea. Point being ask for your doctors suggestion but you may have to try a few.

Post Edited (t331) : 9/19/2017 11:15:21 AM (GMT-6)

Forum Moderator

Date Joined Oct 2008
Total Posts : 7069
   Posted 9/19/2017 12:16 PM (GMT -7)   
Hi Mike

Sorry to hear you are having a tough time at the moment finding the right medication can take time.

GP's usually will prescribe an SSRI as a first option such as Zoloft or Lexapro and if the patient has tried a few of these without success then an SNRI such as Cymbalta and Effexor will be prescribed.

I have been on Lexapro and Cymbalta and imo the Lexapro worked the best and did not cause any side effects. The Cymbalta was good but it was really difficult to stop and gave me a lot of side effects.

I try not to worry about the future -- so I take each day just one anxiety attack at a time.


Diagnosed with:- Asperger's Syndrome, Dyslexia, GAD, Social Anxiety Disorder, Health Anxiety, OCD, Depression and Scheuermann's Disease (Adult)

Medications:- 60mg Prozac, Olanzapine 10mg, Dihydrocodeine 180mg per day
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