I ran across this article / study, which I thought might interest some. Although it wasn’t exactly the kind of thing that made me happy to read.
I suspect that the majority of those who had progression without PSA arise, might be G9 or 10, which are known to sometimes exist without PSA expression. But surprisingly, that was not mentioned in the article. Maybe the studies mentioned it, I don’t know, did not read them.
https://news.cornell.edu/stories/2026/07/psa-levels-alone-may-not-reflect-prostate-cancer-growth
I am not a doctor, just a guy without a prostate
Dx Age 64 Nov 2014, PSA 4.3
BX 3 of 12 cores positive original pathology G6
RALP Jan 6, 2015
Post surgical pathology G7 (3+4), - ECE, - Margins, -LN, -SV
PSA @ 6 weeks 2/15, <02, remained <0.02 until 1/2017, .02, repeat 2/2017, still .02. 5/2017-.033, 8/August 2017- .033 8/17 .046, 3/2018 .060. 6/2018 .068, July 2018 - .08, 8/ 2018, .078, Start ADT+SRT.
Sept 2018 thru May 2022 –PSA = <.05
Decipher test, low risk, .37 score
My story.... tinyurl.com/45w7789x
Every day’s a bonus – Sonny3
Interesting, sounds like they were using conventional imaging, CT and MRI, as PSMA-PET was not viable when they started.
My wife gets PET scans every six months for BCa recurrence. She gets cancer marker blood testing more often but they tend to be unreliable so the scans are the gold standard.
I think men are getting shortchanged on PCa imaging. For example IMHO, a MRI then PSMA scan should be obtained in the diagnosis stage prior to biopsy and treatment. Then some baseline scans sometime after treatment for monitoring.
How’s the non-moderator life going?
7/2018 (66yr), PSA 4.1->5.1
8/2018-MRI PI-RADS 5, MRI guided biopsy, 8/14 cores, G7(4+3)
9/2018-CT/Bone scans clear
11/6/18-RALP Surgery
11/2018-Post-Op Path G7(4+3) Tert Gr5, pT3a pN0, Grp 3, SM, EPE, <3mm
11/2018-Decipher 0.47, Ave Risk
1/2019-Epstein-G9(4+5) Grp 5, pT2x, margin vs. incision not clear
4-6/2019 ART 37 sessions
PSA<0.10: 2019, 2020, 2021, 2022, 2023, 2024, 2025
My wife gets PET scans every six months for BCa recurrence. She gets cancer marker blood testing more often but they tend to be unreliable so the scans are the gold standard.
I think men are getting shortchanged on PCa imaging. For example IMHO, a MRI then PSMA scan should be obtained in the diagnosis stage prior to biopsy and treatment. Then some baseline scans sometime after treatment for monitoring.
How’s the non-moderator life going?
7/2018 (66yr), PSA 4.1->5.1
8/2018-MRI PI-RADS 5, MRI guided biopsy, 8/14 cores, G7(4+3)
9/2018-CT/Bone scans clear
11/6/18-RALP Surgery
11/2018-Post-Op Path G7(4+3) Tert Gr5, pT3a pN0, Grp 3, SM, EPE, <3mm
11/2018-Decipher 0.47, Ave Risk
1/2019-Epstein-G9(4+5) Grp 5, pT2x, margin vs. incision not clear
4-6/2019 ART 37 sessions
PSA<0.10: 2019, 2020, 2021, 2022, 2023, 2024, 2025
Actually this is rather common with men who are castrate resistant. enzalutamide and other meds lower the PSA, but imaging shows the cancer is still progressing.
Read the same Àrticle, need more info. Somewhat concerned
Definitely going to ask my Onc Dr Tanya
Dorff bout this one. I'll post what she says. Also that same day there was another PC article about another miricle drug that has promise. Guess we live daily with potential bad or good news. Just got to keep the faith!
Wings
DX PCa-2012,St 4,GS 3+4,, 4+3=7 w/6 mets PSA=71
Lupron
1/13=2.7 2/13=0.7 3/13=0.2 6 /13=0.1
9/ 13=0.7 11/13=1.4 12/13=2.7 6/14=3.8 8/14=5.2
Zytiga 9/14=1.4
11/14,thru, 8/18=<0.060
12/18 thru 3/22=<0.014
7/22 thru 06/26=<0.008
Definitely going to ask my Onc Dr Tanya
Dorff bout this one. I'll post what she says. Also that same day there was another PC article about another miricle drug that has promise. Guess we live daily with potential bad or good news. Just got to keep the faith!
Wings
DX PCa-2012,St 4,GS 3+4,, 4+3=7 w/6 mets PSA=71
Lupron
1/13=2.7 2/13=0.7 3/13=0.2 6 /13=0.1
9/ 13=0.7 11/13=1.4 12/13=2.7 6/14=3.8 8/14=5.2
Zytiga 9/14=1.4
11/14,thru, 8/18=<0.060
12/18 thru 3/22=<0.014
7/22 thru 06/26=<0.008
The number of men dying from this beast each year is rising, as is the number of men on ADT. Somethings wrong!
Over eight years ago at 0.093, following SRT,
imaging identified multiple suspicious lymph nodes. Six nodes confirmed cancerous by salvage extended pelvic lymph node surgery. I was just a G 4+3.
Today, holding 0.03X since June 2021. Grateful for these five years with no ADT but keeping a very close watch with frequent testing, annual imaging and ctDNA testing.
Benign biopsy at 47-PSA 20.4. Metastatic at 57-PSA 10.1. RP in 2016 followed by SRT to bed. 2018 advanced imaging and SePLND in Europe. Since June 2021 uPSA holding 0.03X, still no ADT. DX'ed metastatic melanoma Sep 2024. Have learned twice to not give cancer time and obscurity. Maintaining excellent health and fitness. Grateful! Murray Keith Wadsworth, author, podcaster: sheeporwolfcancer.com
Over eight years ago at 0.093, following SRT,
imaging identified multiple suspicious lymph nodes. Six nodes confirmed cancerous by salvage extended pelvic lymph node surgery. I was just a G 4+3.
Today, holding 0.03X since June 2021. Grateful for these five years with no ADT but keeping a very close watch with frequent testing, annual imaging and ctDNA testing.
Benign biopsy at 47-PSA 20.4. Metastatic at 57-PSA 10.1. RP in 2016 followed by SRT to bed. 2018 advanced imaging and SePLND in Europe. Since June 2021 uPSA holding 0.03X, still no ADT. DX'ed metastatic melanoma Sep 2024. Have learned twice to not give cancer time and obscurity. Maintaining excellent health and fitness. Grateful! Murray Keith Wadsworth, author, podcaster: sheeporwolfcancer.com
I elected not read the article because it probably would bring me down. It's the main issue that I have concerns about. I keep thinking that at one of my quarterly MO meetings he will suggest it's time for another scan even if it's just a bone scan or even a DEX scan, but he hasn't. I trust his judgement and I'm not inclined to inquire about one.
Part I 2015, Age 54. Age now 66
PSA: 20.8 Bx: All cores G7 (4+3)
RALP & Adjuvant RT
Pathology: G8 (4+4)+5
PSA nadir: 0.1, steady increase
Part II 2019
Lupron/Xtandi, PSA: <0.01 (2019 -2025)
Lupron/Xtandi, PSA <0.1 (2025 - current) Medicare changed me to LabCorp and standard PSA tests
2021: Reclast
2023: Prolia
Part I 2015, Age 54. Age now 66
PSA: 20.8 Bx: All cores G7 (4+3)
RALP & Adjuvant RT
Pathology: G8 (4+4)+5
PSA nadir: 0.1, steady increase
Part II 2019
Lupron/Xtandi, PSA: <0.01 (2019 -2025)
Lupron/Xtandi, PSA <0.1 (2025 - current) Medicare changed me to LabCorp and standard PSA tests
2021: Reclast
2023: Prolia