My symptoms have been well-managed via Humira and the SCD diet.
This past weekend, I tried a CBD oil that has melatonin in it. After 2 nights of the melatonin CBD product l, I developed a flare-up, with the sudden appearance of bloody stools and strong colon cramping.
I'm curious if anyone has ever had a flare triggered by melatonin? The melatonin is the only new thing going on with me.
The other possibility is that this flare was triggered by school stress, or is random.
Any thoughts?
I love melatonin and take it often with no side effects. I think I read that it helps with free radical damage and oxidative stress and is generally protective for us to use. I have had bad gastic distress from cbd oils though so I avoid those. Lots of diarrhea and nausea.
Joanna, 34, Pa
formerly known as bananagirl
Daily fun UC pills: 15 mg Rinvoq, 6-8 Creons, Marinol and Zofran as needed. In remission after bad flare in 2023.
Joanna, 34, Pa
formerly known as bananagirl
Daily fun UC pills: 15 mg Rinvoq, 6-8 Creons, Marinol and Zofran as needed. In remission after bad flare in 2023.
magicbeans said...
My symptoms have been well-managed via Humira and the SCD diet.
This past weekend, I tried a CBD oil that has melatonin in it. After 2 nights of the melatonin CBD product l, I developed a flare-up, with the sudden appearance of bloody stools and strong colon cramping.
I'm curious if anyone has ever had a flare triggered by melatonin? The melatonin is the only new thing going on with me.
The other possibility is that this flare was triggered by school stress, or is random.
Any thoughts?
I don't know if it will bring on a flare or not. I know I cannot take melatonin. I tried it and when I wake up I felt very groggy and sluggish.
MODERATOR-UC FORUM
female - diagnosed with moderately severe proctitis/colitis/mild diverticulitis
6mp - 50 miligrams
Zocor - 40 mg
Zetia - 10 miligrams
Calcium with Vitamin D
Zinc
"Fly under the radar" - Dad -
A flare isn't spontaneous...and I wouldn't think that 2 nights of using melatonin would cause your symptoms as such. If you're already flaring, it could exacerbate symptoms...but more likely a progression.
Melatonin is a hormone...for some with autoimmune issues it's contraindicated.
q
*Heather* I give suggestions, do with them what you will.
Status: ...Asacol 3 @ 2x daily; Salofalk enema @ 3rd night (nightly for flares, tapered back to 3rd night maintenance)
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol 20mg as needed; Esomeprazole 40mg; Pulmicort/Oxeze/Airomir (asthma); Pristiq 50mg (depression); Rosuvastatin 10mg (cholesterol); Telmisartan 80mg + Diltiazem 120mg (BP & PVCs)
~LDN 4.5mg / Celebrex 200mg for pain
~vitamins/minerals/supplements; Probiotics....(Natural Factors Critical Care 55 Billion / Genuine Health Advanced Gut Health 50 billion alternate or both as needed @ bedtime)
~Metamucil capsules 6 @ 2x daily with meals; Vitamin D 3500 IU
~URSO 500mg @ 2x daily for Primary Biliary Cholangitis
~Sjogren's (secondary)...symptomatic treatment
"TREAT (FROM)BOTH ENDS" worth it !!
Melatonin is a hormone...for some with autoimmune issues it's contraindicated.
q
*Heather* I give suggestions, do with them what you will.
Status: ...Asacol 3 @ 2x daily; Salofalk enema @ 3rd night (nightly for flares, tapered back to 3rd night maintenance)
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol 20mg as needed; Esomeprazole 40mg; Pulmicort/Oxeze/Airomir (asthma); Pristiq 50mg (depression); Rosuvastatin 10mg (cholesterol); Telmisartan 80mg + Diltiazem 120mg (BP & PVCs)
~LDN 4.5mg / Celebrex 200mg for pain
~vitamins/minerals/supplements; Probiotics....(Natural Factors Critical Care 55 Billion / Genuine Health Advanced Gut Health 50 billion alternate or both as needed @ bedtime)
~Metamucil capsules 6 @ 2x daily with meals; Vitamin D 3500 IU
~URSO 500mg @ 2x daily for Primary Biliary Cholangitis
~Sjogren's (secondary)...symptomatic treatment
"TREAT (FROM)BOTH ENDS" worth it !!
There is an old thread that ran in the GERD forum about melatonin causing diarrhea, once they stopped using it the diarrhea went away. That thread was about 8 pages long.
Susie
Moderator in Chronic Pain & Psoriasis Forums
Susie
Moderator in Chronic Pain & Psoriasis Forums
@quincy -- That's not true for me. I've had sudden short flares caused by intense emotional distress. For example, I went to visit my mother last Fall, and the distress of the visit triggered a *massive* flare-up the day after my visit with her, that appeared out of nowhere. Bloody stools and cramping for 5 days, and then once I had returned home, the flare had gone.
So I do think that since flares can be triggered by emotional distress, they can also be triggered by disagreeable physical substances.
So I do think that since flares can be triggered by emotional distress, they can also be triggered by disagreeable physical substances.
Hi...I can see it exacerbated, but not from zero to full blown in a day. However...can you use mesalamine at all, as in the retention enemas?
q
*Heather* I give suggestions, do with them what you will.
Status: ...Asacol 3 @ 2x daily; Salofalk enema @ 3rd night (nightly for flares, tapered back to 3rd night maintenance)
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol 20mg as needed; Esomeprazole 40mg; Pulmicort/Oxeze/Airomir (asthma); Pristiq 50mg (depression); Rosuvastatin 10mg (cholesterol); Telmisartan 80mg + Diltiazem 120mg (BP & PVCs)
~LDN 4.5mg / Celebrex 200mg for pain
~vitamins/minerals/supplements; Probiotics....(Natural Factors Critical Care 55 Billion / Genuine Health Advanced Gut Health 50 billion alternate or both as needed @ bedtime)
~Metamucil capsules 6 @ 2x daily with meals; Vitamin D 3500 IU
~URSO 500mg @ 2x daily for Primary Biliary Cholangitis
~Sjogren's (secondary)...symptomatic treatment
"TREAT (FROM)BOTH ENDS" worth it !!
q
*Heather* I give suggestions, do with them what you will.
Status: ...Asacol 3 @ 2x daily; Salofalk enema @ 3rd night (nightly for flares, tapered back to 3rd night maintenance)
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol 20mg as needed; Esomeprazole 40mg; Pulmicort/Oxeze/Airomir (asthma); Pristiq 50mg (depression); Rosuvastatin 10mg (cholesterol); Telmisartan 80mg + Diltiazem 120mg (BP & PVCs)
~LDN 4.5mg / Celebrex 200mg for pain
~vitamins/minerals/supplements; Probiotics....(Natural Factors Critical Care 55 Billion / Genuine Health Advanced Gut Health 50 billion alternate or both as needed @ bedtime)
~Metamucil capsules 6 @ 2x daily with meals; Vitamin D 3500 IU
~URSO 500mg @ 2x daily for Primary Biliary Cholangitis
~Sjogren's (secondary)...symptomatic treatment
"TREAT (FROM)BOTH ENDS" worth it !!
Not good in this new mouse study.
oldmike
https://www.medicalnewstoday.com/articles/melatonin-used-to-promote-sleep-may-worsen-inflammatory-bowel-disease-symptoms
UC-1980 MEDS: None. UC gone. Go Figure.
95+ % Colon left, plus rectal stump.
Stoma name is Laurie,named after it's mommy.
Rectal stump, Death Vader.
oldmike
https://www.medicalnewstoday.com/articles/melatonin-used-to-promote-sleep-may-worsen-inflammatory-bowel-disease-symptoms
UC-1980 MEDS: None. UC gone. Go Figure.
95+ % Colon left, plus rectal stump.
Stoma name is Laurie,named after it's mommy.
Rectal stump, Death Vader.
I've done a little reading on melatonin, and one of the striking things to me was that most folks are dramatically overdosing it. Like we only need .1-.3mg an hour ahead of sleep, not the massive doses often on the shelves. I'm curious what dose you were taking?
In symptomatic remission on Entyvio (started March 2022; waiting on my next scope), plus probiotics, vit D and B complex, magnesium, fish oil, curcumin
Ongoing flaring/remitting uveitis, sacroiliitis, and neck/jaw trouble
In symptomatic remission on Entyvio (started March 2022; waiting on my next scope), plus probiotics, vit D and B complex, magnesium, fish oil, curcumin
Ongoing flaring/remitting uveitis, sacroiliitis, and neck/jaw trouble
Since this thread is from 2024, you’ve likely moved on, but I’ve noticed that additives or carrier oils in CBD drops often trigger flares.
Switching to edibles helped me avoid the gut irritation caused by liquid tinctures.