Hey there - I don't have much experience with the other meds that you mentioned, but I know that even small doses of Effexor did a dooozie on my system. I was lucky that it worked rather well for me when I was a real mess, but I noticed the edginess at times too. I was maxed out at 112.5 mg and that was a lot for me and I could only handle that for a while. I eventually had to scale it back because of the jitteries and the agitation that came from it. I would also get ultra agitated and rammy if I ever missed a pill, even by a half a day. All the usually fogginess and prickly, electric shockies. And I had a heck of a time with the discontinuation even though I followed the dr's orders carefully when I weaned myself off of it. Took almost 4 weeks, before my stomach stopped being upset.
Point of my little ramble: I wouldn't be surprised if the Effexor was causing problems even at the low dose.
Good luck and hope you start to feel better,
Putter
Hey Robert
My pdoc and I had this very conversation last month-he indicated that in his opinion and from some of the new lit that seroquel acts as a mood stabilizer, meaning it helps with depression and mania. That said, I don't think it is used as monotherapy...more as adjunct. Hope that helps...
Shannon2