My BCR story: scheduling my first PSMA-PET scan

My AI gave references for the suggested ranges, which, in the main, vary from 1 to 2 years' worth of data. My R.O. also gave me her figure a couple of readings ago, and it was also >12 months. I just needed some confidence that it's unlikely I'll go much over 0.3 in the next two months--we're waiting for that, regardless of the time that takes. BTW, I believe the MSK calculator assumes a log‑linear rise.

When I entered all my values >0.1 as indicated on the MSK page, it calculated a double time of 16.6 months, which isn't far from to the upper number I cited.

Djin

Post Edited (DjinTonic) : 12/25/2025 2:15:09 AM (GMT-5)

DjinTonic.....not trying to be difficult, but I re-punched in all your numbers and doubling time from MSKCC is 10.9 months.

Even if you just use the 2 values from 8/4/2025 and 12/22/2025 it returns 11 months.

not sure where you are getting 16.6 months....anyway makes no difference.

My brother PSA hit .42 and PSMA scan lit up his prostate bed and a spot on his hip....the biopsy of his hip was negative, but with a disclaimer that they are hard to hit and they could have missed the spot....they then said they would have radiated the spot anyway.....I asked then why bother with the biopsy.....thanks for nothing I told them.
Djin - Your rate of increase per day actually decreased significantly from the previous measurements. 11/10/25 is actually the odd one to me. This makes me think doubling time would be a waste of computational effort. I like to think you have a bunch of 0.2's that may become 0.3's someday and probably not tomorrow.
7/2018 (66yr), PSA 4.1->5.1
8/2018-MRI PI-RADS 5, MRI guided biopsy, 8/14 cores, G7(4+3)
9/2018-CT/Bone scans clear
11/6/18-RALP Surgery
11/2018-Post-Op Path G7(4+3) Tert Gr5, pT3a pN0, Grp 3, SM, EPE, <3mm
11/2018-Decipher 0.47, Ave Risk
1/2019-Epstein-G9(4+5) Grp 5, pT2x, margin vs. incision not clear
4-6/2019 ART 37 sessions
PSA<0.10: 2019, 2020, 2021, 2022, 2023, 2024, 2025
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Hopefully not to ad nauseam, again sharing my different diagnostic and treatment path. Prior to my RP ten years ago I learned to do not give this beast time and obscurity. So eight years ago this week I headed to Radboud UMC, Nijmegen, Netherlands, for Ga68 PMSA PET (they already had solid experience eight years ago), and the 'even better' Ferrotran nanoparticle MRI. That comparative imaging was done at uPSA 0.093, nine months after unsuccessful SRT to prostate bed (shot blind and missed some); pre SRT PSA was 0.113 and post treatment nadir was 0.075.

Although the PSMA PET was clear the Ferrotran MRI identified multiple cancerous pelvic lymph nodes. Six total were confirmed by salvage pelvic lymph node surgery including para-aortic node, using frozen section pathology method at OLV Hospital, Aalst, Belgium. Post SePLND nadir was <0.010. A few years later I learned Kwon supports SePLND and the Mayo offers them on a limited basis, but unfortunately the Ferrotran MRI is still on restricted availability in Europe. I continue to wonder how the Ferrotran MRI would change things here in US; oddly it began as Combidex here in the US in the 1990's.

Today, my uPSA is holding very low stable 0.03X, no ADT. Although I am grateful beyond words I do not dismiss this lingering PSA having had RP, and continue steady watch with quarterly uPSA testing, annual comparative imaging and liquid blood biopsy testing. All the best to all of us!
Benign biopsy at 47 with PSA 20.4. Metastatic disease at 57 with PSA 10.1; otherwise excellent health and fitness. Intent is to defer ADT/CR for as long as possible and no longer give cancer time and obscurity. Treatment path: RP, salvage RT to bed, advanced imaging in Europe, salvage ePLND. Since June 2021 uPSA holding 0.03X range, still no ADT. Murray Keith Wadsworth, author, podcaster.

Post Edited (NanoMRI) : 12/27/2025 9:36:25 AM (GMT-5)

The only reason we were looking at doubling time was to help plan out next steps--and I wanted some degree of assurance that my PSA wasn't likely to skyrocket if I spaced out PSA testing. I think there was some miscommunication also--I and my uro were thinking that my first PSMA-PET scan would be at 0.2; however, my R.O. felt strongly that it would be negative and that it was better to wait for (at least). So I was doing PSA tests every 2 weeks for a while.

My scan should give us good information. If anything shows up, we'll treat. A more difficult decision will be what to do if nothing does: do we zap or do we wait a little longer and rescan. There are quite a few indicators that this is not metasatic disease and is behaving like indolent cancer:

pT2 with negative margins and 16 negative nodes
Low-risk Decipher score
Low (5%) tumor burden
Post-RP PSA nadir <0.010
Late onset of BCR with slow velocity
No red flags (as far as I can tell) in my Decipher Grid report, which, BTW, indicated that my cancer is susceptible to RT.

All that has to be weighed against my Gleason 9 (4+5), which put me in the high-risk group from the outset.

I'll be 78 in April, and I think that should be in the picture. Assuming my PSA will continue to rise, I do want to treat before my PSA reaches 0.5. I'm thinking that the decision will come down to: if the scan is negative, do I treat or wait and rescan at 0.4? (If you zap the fossa or fossa "plus," you don't get to re-zap the whole pelvis if pelvic nodes are later detected.)

Djin
69 yr at Dx, BPH x 20 yr, 9 (!) neg. Bx
2013 TURP for BPH (90-->30 g) no PCa
6-6-17 Nodule (R) + PSA on finasteride: 3.6-->4.3
Bx #10: 2/14 cores: G10 (5+5) 50% RB, G9 (4+5) 3% RLM, nodule neg
Bone scan, CTs: neg, 8-7-17 open RP @Duke, neg frozen sections, nerves spared
SM EPE BNI LVI SVI LNI(16): neg, PNI+, pT2c pN0 R0 MX, G9 (4+5) 5%, 64 g
Decipher 0.37 Low Risk, PSA 0.010 (3m)…0.234 (8+ yr)

Post Edited (DjinTonic) : 12/27/2025 9:35:19 AM (GMT-5)

Medicare paid for my PSMA PETs at 0.03.
Benign biopsy at 47 with PSA 20.4. Metastatic disease at 57 with PSA 10.1; otherwise excellent health and fitness. Intent is to defer ADT/CR for as long as possible and no longer give cancer time and obscurity. Treatment path: RP, salvage RT to bed, advanced imaging in Europe, salvage ePLND. Since June 2021 uPSA holding 0.03X range, still no ADT. Murray Keith Wadsworth, author, podcaster.
My post RALP PSA is slowly rising (for the past year) and has just crossed the 0.10 threshold, so the doctor ordered a TRUS. He said that he'd wait to do a PSMA PET until I hit 0.20 and possibly 0.30. Presumably, that might change based upon the TRUS. He said I'd likely not start treatment until 0.30. In the meantime, I'm hanging loose (in Hawaii) and enjoying the absence of medical treatment.
Age 61 at time of diagnosis, elevated PSA during routine physical prompted investigation
12/20 biopsy: 10/16 cores, Gleason 4 + 3,
2/9/21: RALP at Cottage Hospital, Santa Barbara CA, Dr. Tobis. pT3a N0, Gleason 4 + 3 = 7. PSA still <0.01 30 months post surgery.
Hi Patrick and thanks for joining in to the thread.

You say you've "crossed the 0.10 threshold. What was your last PSA reading?

Remember, "official" BCR is still a confirmed 0.2 and rising, because some folks do plateau. Even if treatment may be a long way off for you, I suggest you think about adding a R.O. to your team should you reach 0.2.

Djin

Post Edited (DjinTonic) : 12/29/2025 5:12:58 PM (GMT-5)

"official" 0.2 is a dated medical industry construct - many centers now use 0.1. Regardless, if cancer at these values how is it not at lower values?

As I share imaging at 0.093 identified multiple lumpy nodes - six confirmed cancerous by salvage pelvic lymph node surgery including para-aortic. Would it have stopped there - IDK? But at 61 not willing to wait and see. All the best to all of us.
Benign biopsy at 47 with PSA 20.4. Metastatic disease at 57 with PSA 10.1; otherwise excellent health and fitness. Intent is to defer ADT/CR for as long as possible and no longer give cancer time and obscurity. Treatment path: RP, salvage RT to bed, advanced imaging in Europe, salvage ePLND. Since June 2021 uPSA holding 0.03X range, still no ADT. Murray Keith Wadsworth, author, podcaster.
Your Dec 25 PSA was a bit higher than anticipated, i.e. 0.242 vs 0.228. (PSADT -> 19.5 months)
Extrapolating on your future PSA count (9 weeks after last) leads to:
23 Feb 2026 -> 0.250
Lets follow how you will fare.
12/2018: Age 69, PSA=7.20, free/total=6.7%.
01/2019: mpMRI -> PIRADS 5, min ADC=4.6.
02/2019: TRUS biopsy-> 6 out of 20 cores positive, GS 4+4=8.
04/2019: PSA=7.66.
05/2019: RALP + frozen sections -> GS=4+5, unilateral SVI, pT3b, pN0 (0/20), R0 (clean margins).
06-12/2019: PSA=0.02.
02/2020 to 11/2021: PSA=0.03 to 0.17, PSADT~9.5 months.
11/2021 Adaptive Bicalutamide MED start
I learned to be mindful of cancer advancing ahead of PSA and imaging. Liquid blood biopsy testing is recognized for identifying metastasis ahead of imaging. LBB identified my metastatic melanoma ahead of imaging. A read for consideration:
https://www.asco.org/abstracts-presentations/242378

note - Justfor_ - I am in the HU penalty box - too outspoken beyond common narratives. (could happen here too?)

Post Edited (NanoMRI) : 12/30/2025 1:51:34 PM (GMT-5)

Hi long-time and esteemed HU comrade NanoMRI,
There are no "penalty boxes" over there, only SoC coersion reforms to freethinkers.
(Apologies Dzin Tonic for hijacking your thread)
12/2018: Age 69, PSA=7.20, free/total=6.7%.
01/2019: mpMRI -> PIRADS 5, min ADC=4.6.
02/2019: TRUS biopsy-> 6 out of 20 cores positive, GS 4+4=8.
04/2019: PSA=7.66.
05/2019: RALP + frozen sections -> GS=4+5, unilateral SVI, pT3b, pN0 (0/20), R0 (clean margins).
06-12/2019: PSA=0.02.
02/2020 to 11/2021: PSA=0.03 to 0.17, PSADT~9.5 months.
11/2021 Adaptive Bicalutamide MED start

DjinTonic said...
Hi Patrick and thanks for joining in to the thread.

You say you've "crossed the 0.10 threshold. What was your last PSA reading?

Remember, "official" BCR is still a confirmed 0.2 and rising, because some folks do plateau. Even if treatment may be a long way off for you, I suggest you think about adding a R.O. to your team should you reach 0.2.

Djin



My PSA became detectable (0.03) in 9/24, then slowly rose to 0.07 in 3/25, then dipped to 0.06 in 6/25, then back to 0.07 in 9/25, then jumped to 0.11 in 12/25. I am seeing the folks at UCSF Medical Center (i.e. Dr. Peter Carroll's team) and they have an RO in the loop. Per their direction, I am testing the PSA every three months.
Patrick, you are certainly in good hands. smile
Thank you, Djin Tonic, for sharing your experiences on this site, because there are readers out there who will glean insight from what you have shared.

Thanks for all the many ways in which you contribute here.

All my best in the NEW YEAR ahead ~
Cyclone ~ # Iowa State University
PSA At Diagnosis In Year 2013 : 138
Initial Diagnosis: Advanced Prostate Cancer, With Metastases In Both Lungs
Age At Diagnosis: 48 years
ADT Treatments: LUPRON, FIRMAGON, & currently ZOLADEX
Subsequent Treatments: Chemotherapy (TAXOTERE) & ZYTIGA & RADIATION
Additional Consultant - Dr. KWON - Mayo Clinic
Current PSA Level: < 0.10 - Undetectable Range - Treatments Ongoing
Thank you, Cyclone, for the kind words. You are a model to all of us. And here's wishing that the New Year brings us all much good health!

Djin

Post Edited (DjinTonic) : 1/2/2026 5:23:44 AM (GMT-5)

I had a scheduled visit with my uro yesterday, and given (1) the plan to have my first PSMA-PET when my PSA reaches 0.3 and (2) my recent PSA values:

09-02-25 0.213
09-17-25 0.182
09-29-25 0.187
10-14-25 0.198
11-10-25 0.234
12-22-25 0.242
02-20-26 0.281

we've decided he should order the scan and, when Duke calls to schedule it, I’ll aim for a date at the end of March/early April, 5-6 weeks from my last reading.

Update: Scan (with Pylarify) is scheduled for April 10.
________________

I learned that my uro's practice-established about 100 years ago (before Duke had a Urology section) and with 3 uros currently---is merging into the Duke hospital system and getting a name change to reflect that (Duke Triangle Urology). I also saw a news story that Duke Healthhas plans to expand in NC, with Charlotte apparently next. Both Duke and UNC health have been building and expanding rapidly throughout this area in recent years.
69 yr at Dx, BPH x 20 yr, 9 (!) neg. Bx
2013 TURP for BPH (90-->30 g) no PCa
6-6-17 Nodule (R) + PSA on finasteride: 3.6-->4.3
Bx #10: 2/14 cores: G10 (5+5) 50% RB, G9 (4+5) 3% RLM, nodule neg
Bone scan, CTs: neg, 8-7-17 open RP @Duke, neg frozen sections, nerves spared
SM EPE BNI LVI SVI LNI(16): neg, PNI+, pT2c pN0 R0 MX, G9 (4+5) 5%, 64 g
Decipher 0.37 Low Risk, PSA 0.010 (3m)…0.281 (8+ yr)

Post Edited (DjinTonic) : 3/10/2026 1:02:58 PM (GMT-4)

Solid plan. Given your long slow rise, I wonder how that affects the probability of finding something? Is PSMA expression affected by rate of rise? Some men find something right away, others require a higher PSA.

The medical situation has been one of consolidation for years in the Twin Cities and probably everywhere. In contrast, the University of MN became part of a private health group, M-Health, which was a couple of merged medical organizations before the University agreement. Basically, there are no individual or small doctor groups around here anymore.
7/2018 (66yr), PSA 4.1->5.1
8/2018-MRI PI-RADS 5, MRI guided biopsy, 8/14 cores, G7(4+3)
9/2018-CT/Bone scans clear
11/6/18-RALP Surgery
11/2018-Post-Op Path G7(4+3) Tert Gr5, pT3a pN0, Grp 3, SM, EPE, <3mm
11/2018-Decipher 0.47, Ave Risk
1/2019-Epstein-G9(4+5) Grp 5, pT2x, margin vs. incision not clear
4-6/2019 ART 37 sessions
PSA<0.10: 2019, 2020, 2021, 2022, 2023, 2024, 2025
I believe it all comes down to the size of the lesion(s). Currently I think the minimum lesion size that lights up is about 4 mm, so, for example, the chances of someone with the a very low PSA like me may or may not have a positive scan depending, perhaps, on whether there is, for example, one "larger" lesion in the fossa--or smaller mets in surrounding nodes (or other tissue) that fly under the "radar."

I'll post when I have the scan results.

Post Edited (DjinTonic) : 2/27/2026 9:18:22 PM (GMT-5)

No, size is a second order prediction variable. The decisive one is the spatial concentration of the radiopharmaceutical. A 1 mm dense/compact tumour can attract enough of the latter such that can glow up, while a 10 mm loosely populated one can get buried into noise. The confusion originates from the image resolution of the PET scanner. Two totally different things.